The police investigats a bizarre murder of high school girl Tomie Kawakami (Miho Kanno). They learn that in the months following the crime, nine students and a teacher have also committed suicide or gone insane. The detective assigned to the case (Tomoro Taguchi) finds out that three years prior, another girl also named Tomie Kawakami was murdered with the exact same traits. With further digging, the police finds out that other girls named Tomie Kawakamis have been murdered, dating all the way back to the 1860s. He luckily tracks down a classmate named Tsukiko (Mami Nakamura), but she is currently suffering from amnesia. The detective begins to learn of a horrifying saga that has lasted more than a century.